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| Nomenclature |
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Symbol:
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Nphs2tm3.1Antc
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Name:
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nephrosis 2 homolog, podocin (human);
targeted mutation 3.1, Corinne Antignac
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MGI ID: |
MGI:4845889 |
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Gene:
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Nphs2
Location:
Chr1:156310735-156328035 bp, + strand
Genetic Position: Chr1,
67.71 cM, cytoband G3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:166320
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 2, and an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette leaving exon 2 floxed. (J:166320)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nphs2 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:166320
Mollet G et al.,
"Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndrome."
J Am Soc Nephrol 2009 Oct;20(10):2181-9
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All: |
1 reference(s)
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Analysis Tools
