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| Nomenclature |
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Symbol:
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Pik3catm1.1Rzl
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Name:
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phosphatidylinositol 3-kinase, catalytic, alpha polypeptide;
targeted mutation 1.1, Richard Z Lin
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MGI ID: |
MGI:4845856 |
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Synonyms: |
p110alphaFlox, pik3ca1 loxP |
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Gene:
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Pik3ca
Location:
Chr3:32397671-32466107 bp, + strand
Genetic Position: Chr3,
15.7 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:166421
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 1, and an FRT and loxP flanked neo cassette was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette leaving exon 1 floxed. (J:166421)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pik3ca Mutation:
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14 strains or lines available |
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| References |
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Original: |
J:166421
Lu Z et al.,
"Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction."
Circulation 2009 Jul 28;120(4):318-25
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All: |
5 reference(s)
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Analysis Tools
