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| Nomenclature |
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Symbol:
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Cthtm1Iish
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Name:
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cystathionase (cystathionine gamma-lyase);
targeted mutation 1, Isao Ishii
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MGI ID: |
MGI:4840236 |
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Gene:
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Cth
Location:
Chr3:157894248-157925077 bp, - strand
Genetic Position: Chr3,
81.55 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:166184
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1 through 4 were replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on liver and kidney extract. (J:166184)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cth Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:166184
Ishii I et al.,
"Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury."
J Biol Chem 2010 Aug 20;285(34):26358-68
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All: |
3 reference(s)
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Analysis Tools
