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| Nomenclature |
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Symbol:
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Tg(Prnp-TARDBP*A315T)23Jlel
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Name:
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transgene insertion 23, Jeffrey L Elliott
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MGI ID: |
MGI:4839643 |
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Synonyms: |
A315T TDP-43 line 23 |
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Transgene:
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Tg(Prnp-TARDBP*A315T)23Jlel
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The mouse promoter drives neuronal expression of the human cDNA with point mutations that result in the amino acid substitution of threonine for alanine at position 315 (A315T). This mutation was identified in human patients with amyotrophic lateral sclerosis with TARDBP proteinopathies. Four lines were established (23, 27, 35, and 61). (J:165985)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:165985
Stallings NR et al.,
"Progressive motor weakness in transgenic mice expressing human TDP-43."
Neurobiol Dis 2010 Nov;40(2):404-14
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All: |
1 reference(s)
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Analysis Tools
