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| Nomenclature |
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Symbol:
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Stk39tm1.2Slin
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Name:
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serine/threonine kinase 39;
targeted mutation 1.2, Shih-Hua Lin
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MGI ID: |
MGI:4838422 |
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Gene:
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Stk39
Location:
Chr2:68210445-68472268 bp, - strand
Genetic Position: Chr2,
39.53 cM, cytoband C3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:165706
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: One loxP site was inserted just 5' of exon 9 and an FRT flanked neomycin selection cassette was placed in intron 10 followed by a second loxP site. The selection cassette was subsequently excised from properly targeted ES cells usin flp recombinase, leaving exons 9 and 10 flanked by loxP sites. Mice were then crossed to transgenic mice expressing Tg(CAG-cre)13Miya to delete exons 9 and 10. (J:165706)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Stk39 Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:165706
Yang SS et al.,
"SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction."
J Am Soc Nephrol 2010 Nov;21(11):1868-77
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All: |
1 reference(s)
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Analysis Tools
