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| Nomenclature |
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Symbol:
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Sp8tm2Smb
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Name:
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trans-acting transcription factor 8;
targeted mutation 2, Sheila M Bell
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MGI ID: |
MGI:4837153 |
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Synonyms: |
Sp8flox |
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Gene:
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Sp8
Location:
Chr12:118846329-118852578 bp, + strand
Genetic Position: Chr12,
63.48 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:86196
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: An FRT flanked neomycin selection cassette and a 5' loxP site were inserted in intron 2. A second loxP site was placed downstream of the zinc finger domain and stop codon in the 3' UTR. The coding sequence of the gene was thus surrounded by loxP sites. Sp8tm1Smb was derived from this allele. (J:86196)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sp8 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:86196
Bell SM et al.,
"Sp8 is crucial for limb outgrowth and neuropore closure."
Proc Natl Acad Sci U S A 2003 Oct 14;100(21):12195-200
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All: |
5 reference(s)
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Analysis Tools
