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| Nomenclature |
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Symbol:
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Jak2tm1(JAK2)Argr
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Name:
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Janus kinase 2;
targeted mutation 1, Anthony R Green
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MGI ID: |
MGI:4836590 |
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Synonyms: |
JAK2F |
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Gene:
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Jak2
Location:
Chr19:29251828-29313080 bp, + strand
Genetic Position: Chr19,
23.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:164539
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed neo stop cassette and a modified human cDNA with nucleotide substitutions that results in the amino acid substitution of phenylalanine for valine at position 617 (V617F) were inserted into exon 2. (J:164539)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Jak2 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:164539
Li J et al.,
"JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia."
Blood 2010 Sep 2;116(9):1528-38
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All: |
1 reference(s)
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Analysis Tools
