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| Nomenclature |
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Symbol:
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Mdm2tm4.1Glo
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Name:
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transformed mouse 3T3 cell double minute 2;
targeted mutation 4.1, Guillermina Lozano
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MGI ID: |
MGI:4835495 |
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Synonyms: |
Mdm2SNP309T |
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Gene:
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Mdm2
Location:
Chr10:117688888-117710758 bp, - strand
Genetic Position: Chr10,
66.32 cM, cytoband C1-C3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:164201
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Intron 1 was replaced with the corresponding human intron 1 with a T in position 309. A floxed neo cassette was also inserted into 3 and then removed via Cre mediated recombination. (J:164201)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mdm2 Mutation:
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30 strains or lines available |
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| References |
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Original: |
J:164201
Post SM et al.,
"A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development."
Cancer Cell 2010 Sep 14;18(3):220-30
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All: |
1 reference(s)
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Analysis Tools
