|
|
| Nomenclature |
|
Symbol:
|
Smotm2.1Amc
|
|
Name:
|
smoothened homolog (Drosophila);
targeted mutation 2.1, Andrew P McMahon
|
|
MGI ID: |
MGI:4834775 |
|
Gene:
|
Smo
Location:
Chr6:29735694-29761365 bp, + strand
Genetic Position: Chr6,
12.36 cM, cytoband A3.3
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:135134
|
|
Parent Cell Line:
| AV3 (ES Cell) |
|
Strain of Origin:
|
129X1/SvJ
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Intragenic deletion |
| |
|
Mutation details: LoxP sites and an frt-flanked neomycin resistance cassette were inserted flanking the first coding exon. A tau-LacZ gene was also inserted 3' to the neomycin resistance gene. A null allele was generated by crossing the loxP-flanked allele to beta-actin-Cre expressing mice, an allele with
germline Cre expression, and subsequently crossing out the Cre transgene by backcrossing to ICR. (J:73071, J:135134)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Smo Mutation:
|
7 strains or lines available |
|
| References |
|
Original: |
J:135134
Goddeeris MM et al.,
"Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development."
Development 2007 Apr;134(8):1593-604
|
|
All: |
3 reference(s)
|
|
Analysis Tools
