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| Nomenclature |
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Symbol:
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Actbtm1(INSR)Dac
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Name:
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actin, beta;
targeted mutation 1, Dominico Accili
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MGI ID: |
MGI:4831148 |
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Synonyms: |
beta/INSR |
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Gene:
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Actb
Location:
Chr5:142903115-142906754 bp, - strand
Genetic Position: Chr5,
81.8 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:91350
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: An IRES, floxed neomycin selectioncassette with a polyadenylation signal, and a human insulin receptor cDNA were inserted downstream of the stop codon of the endogenous gene. Expression of the inserted INSR cDNA requires cre excision of the neomycin cassette. (J:91350)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:91350
Okamoto H et al.,
"Transgenic rescue of insulin receptor-deficient mice."
J Clin Invest 2004 Jul;114(2):214-23
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All: |
3 reference(s)
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Analysis Tools
