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| Nomenclature |
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Symbol:
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Lepre1tm1Dgen
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Name:
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leprecan 1;
targeted mutation 1, Deltagen
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MGI ID: |
MGI:4830452 |
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Gene:
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Lepre1
Location:
Chr4:119232915-119248975 bp, + strand
Genetic Position: Chr4,
55.34 cM, cytoband D1
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Reduced body size and skeletal abnormalities in Lepre1tm1Dgen/Lepre1tm1Dgen mice
Show the 5 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:163884
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1 through 3 were replaced with a lacZ-neo cassette. The absences of transcript expression was confirmed by RT-PCR. (J:163884)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lepre1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:163884
Vranka JA et al.,
"Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones."
J Biol Chem 2010 May 28;285(22):17253-62
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All: |
2 reference(s)
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Analysis Tools
