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| Nomenclature |
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Symbol:
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Jak2tm1.1Jlvl
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Name:
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Janus kinase 2;
targeted mutation 1.1, Jean-Luc Villeval
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MGI ID: |
MGI:4829538 |
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Synonyms: |
Jak2V617F |
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Gene:
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Jak2
Location:
Chr19:29251828-29313080 bp, + strand
Genetic Position: Chr19,
23.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:163497
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: Exon 13 was replaced with one in which a G to T mutation results in an amino acid substitution of phenylalanine for valine at position 617 (V617F). An FRT flanked neo cassette downstream of the modified exon was removed by flp mediated recombination. (J:163497)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Jak2 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:163497
Marty C et al.,
"Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice."
Blood 2010 Aug 5;116(5):783-7
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All: |
3 reference(s)
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Analysis Tools
