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| Nomenclature |
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Symbol:
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Gckm1Rge
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Name:
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glucokinase;
ENU mutation 1, University of Munich
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MGI ID: |
MGI:4820836 |
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Synonyms: |
GLS001, Munich GckM210R |
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Gene:
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Gck
Location:
Chr11:5900820-5950081 bp, - strand
Genetic Position: Chr11,
3.88 cM
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Mutation
origin |
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Strain of Origin:
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C3HeB/FeJ
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: ENU mutagenesis induced a G to T transition at position 629 in exon 6 (NCBI GenBank accession no.
NM_010292). This point mutation results in an amino acid substitution of arginine for methionine at position 210 (M210R). (J:162903)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gck Mutation:
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25 strains or lines available |
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| References |
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Original: |
J:162903
van Burck L et al.,
"Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2)."
Am J Physiol Endocrinol Metab 2010 Mar;298(3):E512-23
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All: |
1 reference(s)
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Analysis Tools
