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| Nomenclature |
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Symbol:
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Traf3ip2adjm
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Name:
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TRAF3 interacting protein 2;
atopic dermatitis from Japanese mice
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MGI ID: |
MGI:4820827 |
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Gene:
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Traf3ip2
Location:
Chr10:39612934-39655307 bp, + strand
Genetic Position: Chr10,
20.86 cM
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Mutation
origin |
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: A spontaneous mutation resulted in a C to T transition in the second exon. The transition results in a C- terminal truncation by changing amino acid 214 from glutamine (CAG) to a stop codon (TAG). RT-PCR showed reduced transcript level and western blots of protein extracts from spleens showed no specific Ab labeling in the positions expected for TRAF3IP2.
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:162859
Matsushima Y et al.,
"An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene."
J Immunol 2010 Aug 15;185(4):2340-9
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All: |
1 reference(s)
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Analysis Tools
