Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro
Transgene Detail
|
|
| Nomenclature |
|
Symbol:
|
Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro
|
|
Name:
|
transgene insertion, Carlo M Croce
|
|
MGI ID: |
MGI:4820820 |
|
Synonyms: |
Emu-miR-29, Tg(Emu-Mir29a,-Mir29b-1,-hrGFP)#Cro |
|
Transgene:
|
Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro
Location:
unknown
|
|
Transgene
origin |
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: The mouse Igh (VH186.2) promoter and the IgH-E mu enhancer drive the expression of Mir29a and Mir29b-1, followed by an IRES-hrGFP, humanized renilla, and the SV40 poly (A).Northern blot analysis using RNAs isolated from spleens showed overexpression of Mir-29a and Mir-29b-1 in both transgenic lines (F1 and F2). This line is a represntative line. (J:162077)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
| References |
|
Original: |
J:162077
Santanam U et al.,
"Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression."
Proc Natl Acad Sci U S A 2010 Jul 6;107(27):12210-5
|
|
All: |
2 reference(s)
|
|
|
Analysis Tools
