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| Nomenclature |
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Symbol:
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Tg(Thy1-PSEN1*G384A)45Jckr
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Name:
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transgene insertion 45, Mathias Jucker
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MGI ID: |
MGI:4819105 |
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Synonyms: |
PS45 |
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Transgene:
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Tg(Thy1-PSEN1*G384A)45Jckr
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A human PSEN1 cDNA with a mutation in the codon for amino acid residue 384 causing a glycine to alanine change (G384A) was placed under the control of the murine Thy1.2 minigene. This mutant form is known to increase Abeta1-42 production. (J:92796, J:163811)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:92796
Herzig MC et al.,
"Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis."
Nat Neurosci 2004 Sep;7(9):954-60
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All: |
6 reference(s)
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Analysis Tools
