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| Nomenclature |
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Symbol:
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Mkl2tm2.1Eno
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Name:
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MKL/myocardin-like 2;
targeted mutation 2.1, Eric N Olson
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MGI ID: |
MGI:4818683 |
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Synonyms: |
MrtfbF |
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Gene:
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Mkl2
Location:
Chr16:13256481-13417529 bp, + strand
Genetic Position: Chr16,
9.24 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:161853
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S/SvEv
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 8 and an frt flanked neo cassette with a 3' loxP site was inserted upstream of exon 8. This exon contains the Srf binding site. Flp mediated recombination removed the neo cassette leaving exon 8 floxed. (J:161853)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mkl2 Mutation:
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29 strains or lines available |
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| References |
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Original: |
J:161853
Mokalled MH et al.,
"Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development."
Development 2010 Jul;137(14):2365-74
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All: |
2 reference(s)
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Analysis Tools
