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| Nomenclature |
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Symbol:
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Gys2tm1.1Pro
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Name:
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glycogen synthase 2;
targeted mutation 1.1, Peter J Roach
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MGI ID: |
MGI:4462836 |
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Synonyms: |
Gys2(Lox) |
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Gene:
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Gys2
Location:
Chr6:142422613-142473109 bp, - strand
Genetic Position: Chr6,
74.04 cM
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Decreased glycogen liver content in Gys2tm1.1Pro/Gys2tm1.1Pro Tg(Alb-cre)21Mgn/0 mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:162043
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 5, and a floxed neo cassette was inserted downstream of exon 6. Cre mediated recombination removes the neo cassette leaving exons 5 and 6 floxed. (J:162043)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gys2 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:162043
Irimia JM et al.,
"Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice."
J Biol Chem 2010 Apr 23;285(17):12851-61
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All: |
1 reference(s)
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Analysis Tools
