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| Nomenclature |
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Symbol:
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Glultm3Whla
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Name:
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glutamate-ammonia ligase (glutamine synthetase);
targeted mutation 3, Wouter H Lamers
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MGI ID: |
MGI:4462791 |
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Synonyms: |
GSfl |
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Gene:
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Glul
Location:
Chr1:153899944-153909723 bp, + strand
Genetic Position: Chr1,
65.43 cM, cytoband G2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:162067
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Parent Cell Line:
| IB10/E14IB10 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: One loxP site was inserted in the 3' end of intron 1. An FRT flanked Pgk-neo-PgkTkselection casette was inserted along with a second loxP site 600 bp downstream from exon 7. The FRT flanked selection cassette was removed by transient transfection using an FLPe expression vector. (J:162067)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Glul Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:162067
He Y et al.,
"Glutamine synthetase deficiency in murine astrocytes results in neonatal death."
Glia 2010 Apr 15;58(6):741-54
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All: |
2 reference(s)
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Analysis Tools
