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| Nomenclature |
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Symbol:
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Fgfr2m1Sgg
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Name:
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fibroblast growth factor receptor 2;
mutation 1, S G Gong
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MGI ID: |
MGI:4461798 |
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Synonyms: |
Fgfr2W290R |
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Gene:
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Fgfr2
Location:
Chr7:130162451-133123350 bp, - strand
Genetic Position: Chr7,
73.19 cM
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Mutation
origin |
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Strain of Origin:
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C3H/HeJ
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: ENU mutagenesis induced nucleotide substitutions in exon 7 that result in the amino acid substitution of arginine for tryptophan at position 290 (W290R). This mutation is predicted to disrupt FGFR2 IIIb and IIIc isoforms. (J:160674)
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Inheritance: | |
Not Specified |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fgfr2 Mutation:
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18 strains or lines available |
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| References |
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Original: |
J:160674
Mai S et al.,
"The missense mutation W290R in Fgfr2 causes developmental defects from aberrant IIIb and IIIc signaling."
Dev Dyn 2010 Jun;239(6):1888-900
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All: |
1 reference(s)
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Analysis Tools
