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| Nomenclature |
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Symbol:
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Ttll1tm1Seto
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Name:
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tubulin tyrosine ligase-like 1;
targeted mutation 1, Mitsutoshi Setou
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MGI ID: |
MGI:4461777 |
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Gene:
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Ttll1
Location:
Chr15:83483772-83510893 bp, - strand
Genetic Position: Chr15,
39.4 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:161297
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S/SvEv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 2 through 4 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on trachea and lung extracts. (J:161297)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Primary Ciliary Dyskinesia (J:161297)
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| References |
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Original: |
J:161297
Ikegami K et al.,
"Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry."
Proc Natl Acad Sci U S A 2010 Jun 8;107(23):10490-5
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All: |
1 reference(s)
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Analysis Tools
