|
|
| Nomenclature |
|
Symbol:
|
Dp(10Prmt2-Pdxk)2Yey
|
|
Name:
|
duplication, Chr 10, Y Eugene Yu 2
|
|
MGI ID: |
MGI:4461400 |
|
Synonyms: |
Dp(10)1Yey, Dp(10Prmt2-Pdxk)1Yey, Dp2Yey, Ts2Yey |
|
Gene:
|
Dp(10Prmt2-Pdxk)2Yey
Location:
unknown
Genetic Position: Chr10,
Syntenic
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:161325
|
|
Parent Cell Line:
| AB2.2 (ES Cell) |
|
Strain of Origin:
|
129S7/SvEvBrd-Hprtb-m2
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutation: | |
Duplication |
| |
|
Mutation details: Cre mediated chromosomal rearrangement between loxP sites in regions proximal to Prmt2 and distal to Pdxk results in duplication of the genes, including Prmt2 and Pdxk, in this approximately 2.3 Mb region that is syntenic with the distal part of human 21q22.3. (J:161325)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:161325
Yu T et al.,
"A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions."
Hum Mol Genet 2010 Jul 15;19(14):2780-91
|
|
All: |
2 reference(s)
|
|
Analysis Tools
