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| Nomenclature |
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Symbol:
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Tg(CAG-Map3k7*K63W)1232Mds
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Name:
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transgene insertion 1232, Michael D Schneider
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MGI ID: |
MGI:4461396 |
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Synonyms: |
CAG-CATlox-TAK1K63W, stop-dnTAK, Tg(ACTB-Map3k7*K63W)1232Mds |
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Transgene:
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Tg(CAG-Map3k7*K63W)1232Mds
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the chicken beta-actin promoter followed by a loxP flanked stop, a kinase-inactive Map3k7 with a K63W mutation, and a polyadenylation signal. Cre mediated recombination removes the stop and allows expression of the kinase-inactive Map3k7 gene. Map3k7 expression is increased about 4 fold and this is the highest expressing line. (J:117108)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:117108
Xie M et al.,
"A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway."
Proc Natl Acad Sci U S A 2006 Nov 14;103(46):17378-83
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All: |
1 reference(s)
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Analysis Tools
