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| Nomenclature |
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Symbol:
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Msh2tm3.1Rak
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Name:
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mutS homolog 2 (E. coli);
targeted mutation 3.1, Raju Kucherlapati
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MGI ID: |
MGI:4460264 |
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Synonyms: |
Msh2G674D |
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Gene:
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Msh2
Location:
Chr17:87672330-87723713 bp, + strand
Genetic Position: Chr17,
57.87 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:161577
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: A floxed neo cassette was inserted upstream of modified exon 13 in which nucleotide substitutions (GGT to GAC) results in the amino acid substitution of aspartic acid for glycine at position 674 (G674D). Cre mediated recombination removed the neo cassette. (J:161577)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Msh2 Mutation:
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44 strains or lines available |
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| References |
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Original: |
J:161577
Kucherlapati MH et al.,
"An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents."
Gastroenterology 2010 Mar;138(3):993-1002.e1
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All: |
1 reference(s)
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Analysis Tools
