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| Nomenclature |
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Symbol:
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Msh2tm2.1Rak
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Name:
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mutS homolog 2 (E. coli);
targeted mutation 2.1, Raju Kucherlapati
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MGI ID: |
MGI:4460262 |
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Synonyms: |
M2CKO, MSH2CKO, MSH2CKO pGKneo flipped ou, Msh2LoxP |
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Gene:
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Msh2
Location:
Chr17:87672330-87723713 bp, + strand
Genetic Position: Chr17,
57.87 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:161577
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Parent Cell Line:
| WW6 (ES Cell) |
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Strain of Origin:
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STOCK 129/Sv and C57BL/6J and SJL
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: An frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 12, and an additional loxP site was inserted downstream of exon 12. Flp mediated recombination removed the neo cassette leaving exon 12 floxed. (J:161577)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:161577
Kucherlapati MH et al.,
"An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents."
Gastroenterology 2010 Mar;138(3):993-1002.e1
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All: |
2 reference(s)
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Analysis Tools
