|
|
| Nomenclature |
|
Symbol:
|
Rnf128tm1Cdon
|
|
Name:
|
ring finger protein 128;
targeted mutation 1, Chen Dong
|
|
MGI ID: |
MGI:4459531 |
|
Gene:
|
Rnf128
Location:
ChrX:139563316-139673145 bp, + strand
Genetic Position: ChrX,
61.35 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:160681
|
|
Parent Cell Line:
| Not Specified (ES Cell) |
|
Strain of Origin:
|
Not Specified
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: Part of exon 4 and all of exons 5 and 6 were replaced with the neomycin resistance gene by homologous recombination. This removed amino acids 283-385, which contains much of the RING domain from the protein product. RT-PCR analysis of various tissues confirmed the region was removed. (J:160681)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Rnf128 Mutation:
|
6 strains or lines available |
|
| References |
|
Original: |
J:160681
Nurieva RI et al.,
"The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation."
Immunity 2010 May 28;32(5):670-80
|
|
All: |
1 reference(s)
|
|
Analysis Tools
