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| Nomenclature |
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Symbol:
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Dot1ltm1Tche
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Name:
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DOT1-like, histone H3 methyltransferase (S. cerevisiae);
targeted mutation 1, Taiping Chen
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MGI ID: |
MGI:4459467 |
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Synonyms: |
Dot1L3lox, DOT1Lbetagal |
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Gene:
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Dot1l
Location:
Chr10:80755206-80795461 bp, + strand
Genetic Position: Chr10,
39.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:161427
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 5 and a floxed beta-geo cassette was inserted downstream of exon 6. (J:161427)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Dot1l Mutation:
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26 strains or lines available |
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| References |
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Original: |
J:161427
Jones B et al.,
"The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure."
PLoS Genet 2008;4(9):e1000190
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All: |
3 reference(s)
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Analysis Tools
