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| Nomenclature |
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Symbol:
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Tg(PLP1*)4Rsj
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Name:
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transgene insertion 4, Ravina Simons Johnson
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MGI ID: |
MGI:4459455 |
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Synonyms: |
ND4 |
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Transgene:
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Tg(PLP1*)4Rsj
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A 2.95 kb fragment of the 5' UTR of the human PLP gene drives expression of a cDNA encoding for the DM-20 isoform of human PLP. The cDNA is followed by the small tumor (t) antigen splicing signals and early region polyadenylation signal of SV40. This line contains about 70 copies of the transgene. Northern blot analysis detected expression of the transgene in the brain but not in the liver or kidney. Northern blot analysis also indicated a reduction in the expression of the endogenous Plp1 gene. (J:24069, J:162843)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:161344
Mastronardi FG et al.,
"Demyelination in a transgenic mouse: a model for multiple sclerosis."
J Neurosci Res 1993 Oct 15;36(3):315-24
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All: |
9 reference(s)
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Analysis Tools
