|
|
| Nomenclature |
|
Symbol:
|
Tg(Mbp-Pad2)28Fgm
|
|
Name:
|
transgene insertion 28, Fabrizio G Mastronardi
|
|
MGI ID: |
MGI:4459094 |
|
Synonyms: |
PD2 |
|
Transgene:
|
Tg(Mbp-Pad2)28Fgm
Location:
unknown
|
|
Transgene
origin |
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A 1.9 kb fragment of the mouse Mbp promoter (from the pMG2 plasmid) drives expression of a 2.3 kb cDNA fragment encoding rat Pad2. This line contains 15 copies of the transgene. Immunohistochemical analysis indicates increased expression in the white matter tracts of the corpus callosum. Immunoslot blot analysis of whole brain homogenates also indicates increased expression in mice at 2 to 6 months of age. Myelin samples from the central nervous system contain increased levels of MBP citrullination. (J:142650)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
| References |
|
Original: |
J:142650
Musse AA et al.,
"Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system."
Dis Model Mech 2008 Nov;1(4-5):229-40
|
|
All: |
1 reference(s)
|
|
Analysis Tools
