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| Nomenclature |
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Symbol:
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Abhd5tm1.1Rze
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Name:
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abhydrolase domain containing 5;
targeted mutation 1.1, Rudolf Zechner
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MGI ID: |
MGI:4456205 |
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Synonyms: |
Cgi-58- |
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Gene:
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Abhd5
Location:
Chr9:122351608-122381524 bp, + strand
Genetic Position: Chr9,
73.03 cM, cytoband F4
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Small size, glossy dry skin, and necrotic tail tip in Abhd5tm1.1Rze/Abhd5tm1.1Rze mice
Show the 5 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:160725
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP site was inserted upstream of exon 4 and a floxed neo cassette was inserted downstream of exon 7. Cre mediated recombination removed exons 4 through 7 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on carcass lipid droplet extracts. (J:160725)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Abhd5 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:160725
Radner FP et al.,
"Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)."
J Biol Chem 2010 Mar 5;285(10):7300-11
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All: |
1 reference(s)
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Analysis Tools
