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| Nomenclature |
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Symbol:
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Lrp4tm2Her
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Name:
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low density lipoprotein receptor-related protein 4;
targeted mutation 2, Joachim Herz
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MGI ID: |
MGI:4455050 |
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Synonyms: |
Lrp4- |
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Gene:
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Lrp4
Location:
Chr2:91457511-91513779 bp, + strand
Genetic Position: Chr2,
50.63 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:156471
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S/SvEv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Exon 1, which encodes the signal peptide and the initiating ATG, was replaced with a neomycin stop cassette. No residual functional protein can be generated. (J:156471, J:160547)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lrp4 Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:156471
Ohazama A et al.,
"A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition."
Proc Natl Acad Sci U S A 2010 Jan 5;107(1):92-7
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All: |
3 reference(s)
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Analysis Tools
