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| Nomenclature |
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Symbol:
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Tg(Fabp4-LMNA*R482Q)11ACdl
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Name:
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transgene insertion 11A, Constantine D Londos
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MGI ID: |
MGI:4453886 |
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Synonyms: |
FPLD |
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Transgene:
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Tg(Fabp4-LMNA*R482Q)11ACdl
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains the fatty acid binding protein 4 (Fabp4/aP2) promoter driving adipose-specific expression of a cDNA encoding the A isoform of human lamin A with substitution of glutamine for arginine at amino acid position 482 followed by an SV40 splice site and poly(A) signal. This amino acid substitution was identified in patients with familial partial lipodystrophy of the Dunnigan type (FPLD2). A mouse line was generated from founder 11A. (J:149858)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:149858
Wojtanik KM et al.,
"The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation."
J Lipid Res 2009 Jun;50(6):1068-79
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All: |
1 reference(s)
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Analysis Tools
