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| Nomenclature |
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Symbol:
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Tg(Prnp-ITM2B*)7Jckr
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Name:
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transgene insertion 7, Mathias Jucker
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MGI ID: |
MGI:4452483 |
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Synonyms: |
ADanPP7, Tg(SHaPrP-BRI2795InsTTTAATTTGT) |
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Transgene:
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Tg(Prnp-ITM2B*)7Jckr
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6N
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene expresses the Danish allele of human ITM2B, which includes a 10-nucleotide duplication (795-796InsTTTAATTTGT) in ITM2B, driven by the Syrian hamster Prnp promoter. Two lines were created (lines 6 and 7) with line 7 exhibiting high levels of transgene expression. (J:159279)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:159279
Coomaraswamy J et al.,
"Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease."
Proc Natl Acad Sci U S A 2010 Apr 27;107(17):7969-74
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All: |
1 reference(s)
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Analysis Tools
