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| Nomenclature |
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Symbol:
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Rab25tm1Jrgo
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Name:
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RAB25, member RAS oncogene family;
targeted mutation 1, James R Goldenring
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MGI ID: |
MGI:4440861 |
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Synonyms: |
Rab25- |
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Gene:
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Rab25
Location:
Chr3:88542029-88548300 bp, - strand
Genetic Position: Chr3,
38.87 cM, cytoband E3-F1
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Rab25tm1Jrgo/Rab25tm1Jrgo ApcMin/Apc+ mice exhibit increased intestinal adenoma formation compared to ApcMin/Apc+ mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:158733
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The neomycin resistance gene along with 3 tandem in-frame stop codons was inserted into the second exon. Western blot and immunostaining indicated a lack of protein expression in the intestines of homozygous mice. (J:158733)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rab25 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:158733
Nam KT et al.,
"Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas."
J Clin Invest 2010 Mar;120(3):840-9
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All: |
1 reference(s)
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Analysis Tools
