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| Nomenclature |
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Symbol:
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Lgi1tm1.1Jkc
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Name:
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leucine-rich repeat LGI family, member 1;
targeted mutation 1.1, John K Cowell
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MGI ID: |
MGI:4439515 |
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Gene:
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Lgi1
Location:
Chr19:38264782-38308939 bp, + strand
Genetic Position: Chr19,
32.9 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:158715
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Cre mediated recombination removed exons 3 through 8 of a MICER clone with a K14-Agouti gene, 3'Hprt, loxP site, and puro cassette inserted downstream of a duplicated exons 1 and 2 and a neo cassette, loxP site, 5'Hprt, and tyrosinase gene inserted downstream of exon 8. The absence of transcript expression was confirmed by RT-PCR analysis on hippocampus and cortex extracts. (J:158715)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lgi1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:158715
Yu YE et al.,
"Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability."
Hum Mol Genet 2010 May 1;19(9):1702-11
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All: |
1 reference(s)
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Analysis Tools
