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| Nomenclature |
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Symbol:
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Tg(HTT*)1Xwy
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Name:
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transgene insertion 1, X William Yang
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MGI ID: |
MGI:4438230 |
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Synonyms: |
SA |
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Transgene:
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Tg(HTT*)1Xwy
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The 240 kb human bacterial artificial chromosome BAC(RP11-866L6), containing the entire 170 kb human Huntingtin (htt) genomic locus and approximately 20 kbp of 5' and 50 kbp of 3' flanking sequences, was modified by replacing the human htt exon 1 with a loxP-flanked human mutant htt exon 1 sequence (containing 97 mixed CAA-CAG repeats encoding a continuous polyglutamine (polyQ) stretch). Nucleotide substitution resulted in amino acid substitution of alanine for serine at positions 13 and 16. One line was created (no line number provided). (J:157723)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:157723
Gu X et al.,
"Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice."
Neuron 2009 Dec 24;64(6):828-40
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All: |
1 reference(s)
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Analysis Tools
