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| Nomenclature |
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Symbol:
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Tg(ACTB-APP*V717F)1Colm
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Name:
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transgene insertion 1, Colin L Masters
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MGI ID: |
MGI:4438112 |
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Synonyms: |
APPC100.V717F, Tg C100.V717F, TgC100.V717F |
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Transgene:
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Tg(ACTB-APP*V717F)1Colm
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The human promoter was used to drive ubiquitous expression of the C-terminal portion of human APP (C100) with an amino acid substitution of phenyalanine for valine at position 717 (V717F), also known as the London mutation. One line was created (no line number given) with 40 to 50 copies of the transgene. (J:55025)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:55025
Li QX et al.,
"Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice."
J Neurochem 1999 Jun;72(6):2479-87
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All: |
2 reference(s)
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Analysis Tools
