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| Nomenclature |
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Symbol:
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Tg(tetO-CUGBP1)3413Coop
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Name:
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transgene insertion 3413, Thomas A Cooper
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MGI ID: |
MGI:4438033 |
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Synonyms: |
TRECUGBP1 |
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Transgene:
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Tg(tetO-CUGBP1)3413Coop
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The tetracycline-responsive element and minimal CMV promoter drives expression of the FLAG-tagged LYLQ isoform of the human cDNA preceded by a genomic fragment containing the untranslated exons 2 and 3 with intron 2 of Myh6 and followed by a bovine hormone polyadenylation site and 3' flanking genomic sequence. Three lines were created (including lines 3413 and 3481). Line 3413 exhibit a 4- to 8-fold induction of exogenous protein expression. (J:157646)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:157646
Koshelev M et al.,
"Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1."
Hum Mol Genet 2010 Mar 15;19(6):1066-75
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All: |
2 reference(s)
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Analysis Tools
