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| Nomenclature |
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Symbol:
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Tg(GFAP-HTT*160Q)31Xjl
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Name:
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transgene insertion 31, Xiao-Jiang Li
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MGI ID: |
MGI:4437299 |
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Synonyms: |
GFAP-HD, Htt-160Q |
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Transgene:
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Tg(GFAP-HTT*160Q)31Xjl
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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FVB/NCrl
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The GFAP-HD transgene was designed containing 208 aa of N-terminal human huntingtin (HTT) gene, containing 160 glutamine residues (160Q), driven by the human glial fibrillary acidic protein (GFAP) promoter, followed by a mouse protamine-1 (MP-1) polyadenylation (polyA) signal. (J:156460)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:156460
Bradford J et al.,
"Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms."
Proc Natl Acad Sci U S A 2009 Dec 29;106(52):22480-5
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All: |
1 reference(s)
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Analysis Tools
