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| Nomenclature |
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Symbol:
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Is(14)2Rdf
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Name:
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insertion, Chr 14, Riccardo Dalla-Favera 2
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MGI ID: |
MGI:4437013 |
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Gene:
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Is(14)2Rdf
Location:
unknown
Genetic Position: Chr14,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:156946
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP and FRT sites as well as a PGK promoter and Hygro cassette were place about 5 kb telomeric to the alternative exon 1 of Dleu2 by homologous recombination. The targeting was done in ES cells carrying
Is(14)1Rdf. The two constructs are in cis configuration.
(J:156946)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:156946
Klein U et al.,
"The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia."
Cancer Cell 2010 Jan 19;17(1):28-40
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All: |
1 reference(s)
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Analysis Tools
