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| Nomenclature |
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Symbol:
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Ctsztm1Thre
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Name:
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cathepsin Z;
targeted mutation 1, Thomas Reinheckel
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MGI ID: |
MGI:4436876 |
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Synonyms: |
Ctsz- |
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Gene:
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Ctsz
Location:
Chr2:174427493-174439039 bp, - strand
Genetic Position: Chr2,
97.94 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:157541
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Part of exon 2, which contains the active site cysteine critical for enzyme activity, and part of intron 3 were deleted by homologous recombination and replaced by a cassette comprising an independent ribosomal entry sequence (IRES), followed by a lacZ reporter gene and a neomycin cassette. Disruption of the gene was confirmed by RT-PCR and Western blot analyses. (J:157541)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ctsz Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:157541
Sevenich L et al.,
"Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice."
Proc Natl Acad Sci U S A 2010 Feb 9;107(6):2497-502
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All: |
3 reference(s)
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Analysis Tools
