Smoc1tm1a(EUCOMM)Wtsi
Targeted Allele Detail
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| Nomenclature |
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Symbol:
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Smoc1tm1a(EUCOMM)Wtsi
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Name:
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SPARC related modular calcium binding 1;
targeted mutation 1a, Wellcome Trust Sanger Institute
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MGI ID: |
MGI:4431709 |
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Synonyms: |
Smoc1tm1a |
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Gene:
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Smoc1
Location:
Chr12:81026808-81186414 bp, + strand
Genetic Position: Chr12,
37.28 cM
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Ophthalmo-acromelic-like phenotype in Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Mutant Cell Lines:
| EPD0348_1_A01, EPD0348_1_B01, EPD0348_1_C02, EPD0348_1_C03, EPD0348_1_D01, EPD0348_1_E01, EPD0348_1_E02, EPD0348_1_F01, EPD0348_1_F03, EPD0348_1_F04, EPD0348_1_G02, EPD0348_1_H02, EPD0348_1_H03 (Wellcome Trust Sanger Institute) |
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Germline Transmission:
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Earliest citation of germline transmission:
J:174198
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Parent Cell Line:
| JM8A1.N3 (ES Cell) |
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Strain of Origin:
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C57BL/6N-Atm1Brd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion Vector: L1L2_Bact_P |
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Mutation details: The L1L2_Bact_P cassette was inserted at position 81135318 of Chromosome 12 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 81136165. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:155845, J:173534)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:155845
Wellcome Trust Sanger Institute,
"Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute"
MGI Direct Data Submission 2010;():
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All: |
5 reference(s)
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Analysis Tools
