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| Nomenclature |
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Symbol:
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Corttm1(cre)Zjh
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Name:
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cortistatin;
targeted mutation 1, Z Josh Huang
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MGI ID: |
MGI:4431363 |
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Synonyms: |
Cst-2A-Cre |
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Gene:
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Cort
Location:
Chr4:149125034-149126763 bp, - strand
Genetic Position: Chr4,
78.89 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:151755
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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C57BL/6 x 129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was designed to insert a T2A oligopeptide that mediates ribosomal skipping (foot-and-mouth disease virus 2A from the insect Thosea asigna virus), a cre recombinase sequence, an SV40 polyA signal, and an frt-flanked neo cassette into the 3' untranslated region (after the translational termination site) of the cortistatin locus (Cort). This construct was electroporated into C57BL6/S129 hybrid embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient tetraploid blastocysts. Chimeric mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background) to generate the colony and remove the neo selection cassette. The FLPe transgene has been bred out of the line. (J:151755)
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Recombinase activity
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Activity in:
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nervous system,
postnatal-other,
renal & urinary system,
reproductive system,
respiratory system
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Not detected in:
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adipose tissue,
alimentary system,
cardiovascular system,
embryo-other,
endocrine system,
hemolymphoid system,
integumental system,
liver & biliary system,
muscle,
sensory organs
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Driver:
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Cort
Summary of all recombinase alleles
driven by Cort.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
ES cell line = C57BL6/129S hybrid cells
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| References |
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Original: |
J:151755
NIH Neuroscience Blueprint Cre Driver Network,
"Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network"
MGI Direct Data Submission 2009;():
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All: |
4 reference(s)
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Analysis Tools
