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| Nomenclature |
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Symbol:
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Npc1tm1.1Apl
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Name:
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Niemann Pick type C1;
targeted mutation 1.1, Andrew P Lieberman
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MGI ID: |
MGI:4431252 |
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Synonyms: |
Npc1flox |
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Gene:
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Npc1
Location:
Chr18:12189693-12236400 bp, - strand
Genetic Position: Chr18,
6.15 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:157113
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Parent Cell Line:
| Bruce 4 (ES Cell) |
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Strain of Origin:
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B6.Cg-Thy1a
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Exon 9 was floxed. An frt-flanked neo cassette inserted downstream of exon 9 was removed by flp mediated recombination. (J:157113)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Npc1 Mutation:
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13 strains or lines available |
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| References |
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Original: |
J:157113
Elrick MJ et al.,
"Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration."
Hum Mol Genet 2010 Mar 1;19(5):837-47
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All: |
2 reference(s)
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Analysis Tools
