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| Nomenclature |
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Symbol:
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Fa2htm1.1Hama
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Name:
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fatty acid 2-hydroxylase;
targeted mutation 1.1, Hiroko Hama
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MGI ID: |
MGI:4430585 |
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Synonyms: |
Fa2h- |
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Gene:
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Fa2h
Location:
Chr8:111345135-111393824 bp, - strand
Genetic Position: Chr8,
57.98 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:171655
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP site was inserted in intron 4 and an FRT flanked neo cassette and loxP site were inserted in intron 6 via homologous recombination. Cre mediated recombination removed exons 5 and 6 and the neo cassette. Homozygous mice express a shorter mRNA form at levels similar to expression of the full length form in wild-type mice. (J:171655)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fa2h Mutation:
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1 strain or line available |
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| References |
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Original: |
J:171655
Potter KA et al.,
"Central nervous system dysfunction in a mouse model of Fa2h deficiency."
Glia 2011 Jul;59(7):1009-21
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All: |
1 reference(s)
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Analysis Tools
