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| Nomenclature |
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Symbol:
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Fgfr2tm2Ewj
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Name:
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fibroblast growth factor receptor 2;
targeted mutation 2, Ethylin Wang Jabs
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MGI ID: |
MGI:4430185 |
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Synonyms: |
Fgfr2P253Rneo |
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Gene:
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Fgfr2
Location:
Chr7:130162451-133123350 bp, - strand
Genetic Position: Chr7,
73.19 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:156940
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: A C to G transversion results in the amino acid substitution of arginine for proline at position 253 (P253R). A floxed neo cassette was used for selection purposes. (J:158773)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fgfr2 Mutation:
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18 strains or lines available |
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| References |
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Original: |
J:156940
Aldridge K et al.,
"Brain phenotypes in two FGFR2 mouse models for Apert syndrome."
Dev Dyn 2010 Jan 13;239(3):987-997
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All: |
3 reference(s)
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Analysis Tools
