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| Nomenclature |
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Symbol:
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Fgfr4tm1Axul
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Name:
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fibroblast growth factor receptor 4;
targeted mutation 1, Axel Ullrich
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MGI ID: |
MGI:4429449 |
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Gene:
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Fgfr4
Location:
Chr13:55152640-55168759 bp, + strand
Genetic Position: Chr13,
29.8 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:156750
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: A loxP flanked Neo cassette was inserted into intron 10 and a single nucleotide substitution that resulted in an amino acid substitution of Glycine 385 to Arg was inserted into exon 8 by homologous recombination. (J:156750)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fgfr4 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:156750
Seitzer N et al.,
"A single nucleotide change in the mouse genome accelerates breast cancer progression."
Cancer Res 2010 Jan 15;70(2):802-12
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All: |
2 reference(s)
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Analysis Tools
