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| Nomenclature |
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Symbol:
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Del(11Sparc-Gpx3)91Anjm
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Name:
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deletion, Chr 11, Andrew N J McKenzie
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MGI ID: |
MGI:4421679 |
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Gene:
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Del(11Sparc-Gpx3)91Anjm
Location:
unknown
Genetic Position: Chr11,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:155870
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Deletion, Insertion |
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Mutation details: This deletion was created by cre mediated recombination of loxP sites within Sparc (created by eliminating exon 6 and replacing it with a Neo-LoxP as well as inserting stop codons in all three reading-frames) and beyond Gpx3 (created by random insertion vector of loxP-Puro cassette). The deletion spans an interval of between 0.7 Mb to 1.5 Mb, between Sparc and Gpx3 and includes Fat2, Gm2a, Anxa6, and Tnip1. (J:155870)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Del(11Sparc-Gpx3)91Anjm Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:155870
Barlow JL et al.,
"A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome."
Nat Med 2010 Jan;16(1):59-66
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All: |
1 reference(s)
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Analysis Tools
