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| Nomenclature |
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Symbol:
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Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte
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Name:
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transgene insertion 10, TaconicArtemis
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MGI ID: |
MGI:4417910 |
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Synonyms: |
ARTE10, Tg(Thy1-PSEN1*M146V/Thy1-APP*swe)10Arte |
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Transgene:
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Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene is composed of two constructs containing the Thy1 promoter driving expression of human PSEN1 with the amino acid substitution of valine for methionine at position 146 and human APP with the Swedish familial Alzheimer disease mutation (K670N, M671L). Line 10 (also known as 10-279) was selected as the representative line. (J:155410)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:155410
Willuweit A et al.,
"Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease."
PLoS One 2009;4(11):e7931
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All: |
2 reference(s)
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Analysis Tools
