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| Nomenclature |
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Symbol:
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Tg(KRT14-COL7A1*)1Shzu
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Name:
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transgene insertion 1, Hiroshi Shimizu
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MGI ID: |
MGI:4417882 |
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Synonyms: |
COL7K14-deltah+ |
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Transgene:
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Tg(KRT14-COL7A1*)1Shzu
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutation: | |
Insertion |
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Mutation details: The human promoter was used to drive epidermis-specific expression of the human cDNA with the c.7528delG mutation. This mutation creates a premature stop codon 18 bp downstream of the end of the collagenous domain. Several lines were created with most robust expressing line was selected as the representative line. No line numbers given. (J:155326)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:155326
Ito K et al.,
"Keratinocyte-/fibroblast-targeted rescue of Col7a1-disrupted mice and generation of an exact dystrophic epidermolysis bullosa model using a human COL7A1 mutation."
Am J Pathol 2009 Dec;175(6):2508-17
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All: |
1 reference(s)
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Analysis Tools
